Behavioral Variant Frontotemporal Dementia Performance on a Range of Saccadic Tasks.

Abstract

Saccadic paradigms display changes across a number of degenerative conditions reflecting changes in the oculomotor pathway which in some conditions have been linked to disease presentation. To examine a novel range of saccadic paradigms in behavioral variant frontotemporal dementia (bvFTD). Prosaccade, predictive, self-paced, memory-guided, and anti-saccade tasks were examined in bvFTD patients and controls. A significant increase in latency for the bvFTD group was seen in all tasks. Self-paced saccades are reduced in number, memory-guided saccades display an increase in errors. Predictive saccades show an increased latency that does not remain when prosaccade latency changes are accounted for. While changes were seen across a range of paradigms, no individual task completely separated bvFTD from control participants. bvFTD patients as a group display a number of changes on saccadic testing which may reflect the frontal lobe changes seen in this condition.