Abstract
The case of a 6-year-old boy is presented who developed a stereotyped behavioral response to a wide range of sympathomimetics and minor central nervous system stimulants. The behavioral changes closely resembled the existing descriptions of mania in childhood. Since the boy's mother suffers from bipolar manic-depression, and some of her manic episodes have been secondary to sympathomimetics, we hypothesize that her son is showing a similar profile of behavioral reactivity and that in him, it is a behavioral marker of the genetic predisposition to bipolar manic-depression. The relevant literature is reviewed and certain ethical issues are highlighted.
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