Abstract
The effect of a focus of tonic pain (a subcutaneous injection of formalin into the dorsal field of the shin) on the thresholds of a defense reaction, an attempt to jump out of the chamber in response to a nociceptive electrocutaneous stimulation of the hindpaw1, was studied in the 20– 25-day-old and adult rabbits. The tonic pain produces a biphasic reduction of the defense reaction threshold. At the first phase, hyperalgesia is more pronounced than in the second one, but its duration is shorter. Changes in pain sensitivity in the rabbits proceed in the same direction in both age groups and coincide in time with increase of specific behavioral responses to the formalin injection (licking and shaking the paw). In the 20–25-day-old rabbits the reduction of the threshold of the defense reaction and duration of hyperalgesia phases are more pronounced than in adult animals.
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