Abstract
The utilization of systemically injected leucine-H 3 by the brain was compared in visually-deprived rats and rats receiving prolonged training in a maze on a series of visual pattern-discrimination tasks. Microdensitometric evaluation of autoradiographic grain density over single nerve cells in a variety of visual and nonvisual brain regions indicated that there was no significant difference in the utilization of the radiochemical by proteins of the brain in the two groups of animals; though there was a trend of increased uptake in several visual and nonvisual structures in the visually-deprived animals. This result supports our previous conclusion that the presumed functional activation of the brain by behavioral engagement need not lead to increased protein metabolism, as measured by our technique. The slight increase in the utilization of leucine-H 3 in the visually-deprived animals can be attributed to the greater stress produced by the injection procedure in these unhandled animals.
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