Abstract
The Blood Brain Barrier (BBB) in Non-Human Primates (NHP) can be non-invasively opened through the use of Focused Ultrasound (FUS) in conjunction with microbubbles. This procedure allows for a targeted, transient opening in the BBB of the NHP which can be utilized to facilitate drug delivery. While FUS has been used to deliver various pharmacological compounds to promote neurogenesis or treat cancer, no group has investigated if drug delivery can affect behavioral responses. In this study, we show the effects of targeted ME-FUS drug delivery on the responses of NHP to a decision making task.
Highlights
Background/introduction The Blood Brain Barrier (BBB) in Non-Human Primates (NHP) can be non-invasively opened through the use of Focused Ultrasound (FUS) in conjunction with microbubbles
We show the effects of targeted ME-FUS drug delivery on the responses of NHP to a decision making task
The BBB was successfully opened in the putamen region of each NHP for all ME-FUS procedures
Summary
Background/introduction The Blood Brain Barrier (BBB) in Non-Human Primates (NHP) can be non-invasively opened through the use of Focused Ultrasound (FUS) in conjunction with microbubbles. Behavioral effects of targeted drug delivery via non-invasive microbubble enhanced focused ultrasound blood brain barrier opening in non-human primates From Current and Future Applications of Focused Ultrasound 2014.
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