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Abstract
The effects of the μ-selective agonist DAMGO (ICV doses of 0.00, 0.01, 0.1, or 1.0 μg), the δ-selective agonist DPDPE (ICV doses of 0.00, 0.1, 1.0, or 10.0 μg), and the κ-selective agonist DAKLI (ICV doses of 0.00, 0.01, 0.1, or 1.0 μg) were tested in rats for 60 min in an activity monitor. The durations in seconds of linear locomotor time, rearing time, stereotypy time, and margin time (thigmotaxis) were measured during six 10-min time blocks. DAMGO (0.1 and 1.0 μg) resulted in biphasic effects, inhibition followed by hyperactivity for linear locomotor, rearing, and stereotypy times, and an inhibition of thigmataxis. DPDPE (10.0 μg) was associated with monophasic potentiation of linear locomotor activity and mixed effects in stereotypy times. DAKLI did not effect horizontal, rearing, or margin times; only stereotypy times resulted of in mixed effects of DAKLI. THe differentail behavioral profiles were discussed in reference to the three opioid receptor subtypes.
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