Abstract
Behavioral Effects of Multiple Adrenal Medullary Grafts in Longtailed Macaques
Highlights
A simple quantitative assay has been developed for comparing the behavioral effects of a variety of intracerebral treatments on lesioninduced deficits, in a non-human primate model of Parkinson’s disease /5/
The assay indicated that grafts which succeeded in treating larger striatal regions produced relatively greater behavioral effects
Spontaneous ipsilateral bias was induced by 6-OHDA lesions in 6 of the 7 subjects receiving ribbon grafts and in 16 of the 17 other subjects
Summary
A simple quantitative assay has been developed for comparing the behavioral effects of a variety of intracerebral treatments on lesioninduced deficits, in a non-human primate model of Parkinson’s disease /5/. The assay indicated that grafts which succeeded in treating larger striatal regions produced relatively greater behavioral effects. Preparation of long, narrow "ribbons" and delivery without deformation, in 7 subjects, provided thousands of viable, tyrosine hydroxylaseimmunoreactive cells in 3-10 transplant sites, in evidence as long as 8 weeks after transplantation /2,3/.
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