Abstract
Bilateral intrastriatal 5-μl microinjections of p-hydroxyamphetamine (100 μg/ side) and of dopamine (200 μg/side) were made in awake rats. Neither drug passes the blood-brain barrier well. The injections gave rise to a stereotyped hyperactive behavior similar to that seen after subcutaneous injection of amphetamine. Control injections in the thalamus and hippocampus were without effect, neither were injections of noradrenaline (100–200 μg side) in the corpus striatum. Spreading of tritiated dopamine intracerebrally was controlled by using autoradiography and scintillation counting. These experiments, along with earlier ones, strongly indicate that the amphetamine-type of stereotyped behavior is mediated through dopaminergic mechanisms in the corpus striatum.
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