Abstract
Acute administration of alpha-benzyl-N-methylphenythylamine (ABNMP) induces lateral heavings, straub tail, backward locomotion, and hindlimb abduction—which are all components of the serotonin (5-HT) syndrome. Ketanserin, a 5-HT-2 receptor antagonist and pretreatment with 5-HT neurotoxin parachlorophenylalanine (PCPA) attenuated the manifestation of these behavioral abnormalities. These results suggest that ABNMP may cause an acute release of 5-HT similar to that elicited by parachloramphetamine.
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