Behavioral and physiological effects of photoperiod-induced migratory state and leptin on a migratory bird, Zonotrichia albicollis: I. Anorectic effects of leptin administration

Abstract

The hormone leptin is involved in the regulation of energy balance in mammals, mainly by reducing food intake and body adiposity and increasing energy expenditure. During energetically demanding periods, leptin’s action is often altered to facilitate fat deposition and maintain high rates of food intake. Despite the present controversy over the existence of an avian leptin, there is evidence that a leptin receptor exists in birds and its activation influences energy intake and metabolism. However, it is unknown whether the effects of the activation of leptin receptor on energy balance are modulated during migration. We manipulated photoperiod to induce migratory behavior in captive white-throated sparrows ( Zonotrichia albicollis) and injected migratory and wintering sparrows with either murine leptin or PBS for 7 days. We measured food intake, changes in body composition and foraging behavior to test if leptin’s effects are altered during migratory state. Leptin decreased foraging behavior, food intake and fat mass in wintering sparrows, but had no effect on foraging behavior or food intake in migratory sparrows. Migratory sparrows injected with leptin maintained fat better than sparrows injected with PBS. Thus, sparrows’ responses to leptin changed with migratory state, possibly to aid in the increase and maintenance of rates of food intake and fat deposition. We also found that long-form leptin receptor and SOCS3 were expressed in tissues of sparrows, including the hypothalamus, but their expression did not change with migratory state. Further study of the leptin receptor system and other regulators of energy balance in migratory birds will increase our understanding of the physiological mechanisms that are responsible for their ability to complete energetically demanding journeys.