Abstract
Caffeine is known to exert psychostimulant effects both in man and in animals and it has been shown to modify the levels of brain neurotransmitters. In normal and isolated-aggressive mice, caffeine induces modifications of both the level and the turnover of brain serotonin. Such modifications are however more evident in normal than in aggressive mice. Moreover, caffeine shows an antiaggressive effect and increases the exploratory activity of aggressive mice, without altering the performance of normal animals. It seems possible to conclude that the biochemical and behavioral effects of this drug differ in extent and intensity depending upon the emotional baseline on which it acts.
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