Abstract
D-Lysergic acid diethylamide tartrate (LSD) was evaluated in cats with permanently implanted electrodes for effects on behavior-EEG correlations and on rates of responding for electrical stimulation to the lateral hypothalamus (self-stimulation) and responding for milk reward. Doses of 10 and 15 mcg./Kg. of LSD intraperitoneally increased responding for lateral hypothalamic self-stimulation, stimulated observable behavior, and caused a low-voltage fast cortical EEG to predominate. A dose of 25 mcg./Kg. of LSD produced slight decreases in self-stimulation responding. It also caused disorientation, howling, and periodic pacing and staring. This behavior was associated with a change in EEG pattern toward a slow-wave high-voltage response.
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