Abstract
Protein-calorie undernutrition in the period of rapid brain growth during gestation and suckling in DBA/2J mice resulted in persistent reduction in body and brain weights, despite normal diet from weaning. No significant changes in brain or spinal cord were observed with light microscopy. Behavioral tests revealed that experimental animals had more frequent feeding with smaller meal size, increased activity in the presence of environmental stimulation, fewer errors in learning spatial discrimination reversals, and more errors in problemsolving maze tests. Activity in dark environment, bar pressing for food on a progressive ratio schedule, and foot shock avoidance conditioning showed no significant difference between control and experimental groups. This behavioral profile supports an hypothesis of higher set-point for arousal resulting from early life nutritional deprivation which influences reversal learning and problem solving.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
