Abstract
The present study was undertaken to define more precisely the mechanisms involved in the toxicity of ingested concanavalin A (Con A) in rats, by observation of its behavior in the gastrointestinal tract. Con A was observed to have a high affinity for water-insoluble components of feces. The addition of a massive amount of the water-insoluble components to a high sucrose diet (HSD) containing Con A did not ameliorate the adverse effect of ingested Con A on the adaptive response of the intestinal sucrase activity to dietary sucrose. The addition of Con A bound feces to HSD also prevented the adaptive response of the intestinal sucrase activity to dietary sucrose. The luminal pH of the stomach 5 hr after HSD administration was 3 to 4, which extremely reduced the affinity of Con A for carbohydrate moieties of the cell membrane, whereas those of the jejunum and cecum ranged from 6 to 7. These results substantiate the proposed mechanism, that is, that the toxicity of ingested Con A involves its binding to the l...
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