Abstract
Muscle cell-enriched primary cell cultures were prepared from 8-day embryonic chick heart ventricles. Immunostaining with an anti-EGF antibody detected the presence of EGF in the heart muscle cells, in a perinuclcar distribution. In addition, some of the EGF appeared to be associated with the sarcomercs. Moreover, immunostaining with an anti-EGF receptor antibody also detected perinuclear localization, albeit not among the sarcomeres. Previous studies have shown that the heart muscle and non-muscle cells in culture respond to EGF to increase [3H]thymidine incorporation and cell division (Lau, 1993b). These data suggest the roles of EGF as a natural regulator in the development of the embryonic chick heart
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