Abstract
In experimental work with filtrates of cultures of typhoid bacilli Shwartzman1 observed a new immunological phenomenon in 1928. This phenomenon is elicited by means of a single preparatory intradermal injection of a small amount of a given bacterial filtrate followed twenty to forty-eight hours later by an intravenous injection of the same or another bacterial filtrate. Following the second injection there appears at the site of the preparatory injection in the majority of rabbits pronounced hemorrhagic lesions which bring about necrosis and ulceration. These experiments were confirmed by Burnet,2 Gratia and Linz3 and also the author of this paper in collaboration with Appelmans.4 Gratia and Linz5 attempted to demonstrate the relationship of this phenomenon to anaphylactoid reactions described by Sanarelli6 and phenomenon of Arthus. The Shwartzman phenomenon can be elicited only with certain bacterial filtrates, including those of cholera vibrio as shown by Gratia and Linz, who employed the latter filtrates in a considerable number of experiments. The author of this paper attempted to determine whether EL Tor vibrios behave in the same manner as cholera vibrio towards the Shwartzman phe-
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