Abstract
IN THE following experiments a study was made of the effects produced by pancreatectomy on spontaneous activity, food and water intake, vaginal smears and on the endocrine glands of female rats. METHODS Spontaneous activity was measured by means of cages described in detail else′ where (i). Each cage consisted of a revolving drum with a cyclometer, a living com′ partment with a graduated inverted water bottle and a food cup. Records of activity, food and water intake, and vaginal smears were made daily. The animals were weighed weekly. The rats were placed in the cages at an average age of 47 days, depancreatiz,ed at an average age of 65 days, and autopsied 40 days later. At autopsy the ovaries, spleen, adrenals, pituitary, thyroid and thymus were weighed and preserved for histological study.
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