Abstract
Background: CRMP2 was the first identified CRMP family member as an intracellular molecule that mediates the signaling of Semaphorin-3A (Sema3A). In Sema3A signaling, Cdk5 primarily phosphorylates CRMP2 at Ser522. GSK3 β, and subsequently phosphorylates the residues of Thr509 and Thr514 of CRMP2. These modulations are essential for Sema3A signaling in the neurons. Previously we created CRMP2 S522A knock-in (crmp2ki/ki) mice and demonstrated severe irregular basal dendritic projection of the layer V cortical neurons in the double mutant crmp2ki/ki and crmp1-/- mice. This suggests that the phosphorylation of CRMP2 at Ser522 and synergistic function of both CRMP1 and CRMP2 are critical for normal dendrite patterning in cortical neurons.
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