Abstract
Nephrotoxicity is the most prevalent side effect of the anticancer drug cisplatin (Cis). This study aimed to assess the influence of beetroot (Br) or/ and BM-MSCs on cisplatin-induced nephrotoxicity in male rats. Fifty adult male rats were separated to, Group 1: control. Group 2: Received Cis (7mg/kg b.wt.) once a week for two weeks. Group 3: Rats were given Cis then Br (500m/kg b.wt) daily for four weeks. Group 4: Rats received Cis then injected with a total dose of BM-MSCs (1×106 cell). Group 5: Rats received both Br and BM-MSCs after Cis administration. The results confirmed that Cis raised creatinine, UA, BUN, urea, and MDA while decreasing GSH and catalase. Anti-apoptotic BCL2, EGF, and VEGF levels were reduced. Multiple damages were discovered during the histopathological and histochemical studies of renal tissue. TUNEL and TNF-α expression increased, but PCNA and IL-10 expression decreased in the immunohistochemical investigation. BR or/and BM-MSCs treatment improved biochemical studies in renal tissue besides histological, histochemical, and immunohistochemical studies. The present findings suggested that BR and BM-MSCs significantly impact the kidney's architecture and functional performance.
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