Abstract
The present study aims to investigate the protective effect of bees' honey against metanil-yellow-induced hepatotoxicity in rats. Rats were divided into 7 groups: control group; three groups treated with 50, 100, and 200 mg/kg metanil yellow, and three groups treated with metanil yellow plus 2.5 mg · kg−1 · day−1 bees' honey for 8 weeks. The obtained data showed that the antioxidant/anti-inflammatory activity of bees' honey reduced the oxidative stress in the liver tissue and downregulated the inflammatory markers. In addition, the elevated levels of AGE and the activated NF-κB in the metanil-yellow-treated animals were significantly attenuated. Moreover, the levels of TNF-α and IL-1β were significantly attenuated as a result of bees' honey administration. Furthermore, the histopathological examination of the liver showed that bees' honey reduced fatty degeneration, cytoplasmic vacuolization, and necrosis in metanil-yellow-treated rats. In conclusion, the obtained data suggest that bees' honey has hepatoprotective effect on acute liver injuries induced by metanil-yellow in vivo, and the results suggested that the effect of bees' honey against metanil yellow-induced liver damage is related to its antioxidant/anti-inflammatory properties which attenuate the activation of NF-κB and its controlled genes like TNF-α and IL-1β.
Highlights
The use of metanil yellow as a colorant agent is not permitted, it is still widely used as a colorant in many food industries
There were no differences in the initial body weights of all groups
There was a significant decrease in the body weights of metanil-yellow-treated groups when compared to control group
Summary
The use of metanil yellow as a colorant agent is not permitted, it is still widely used as a colorant in many food industries. Because of its orange-yellow color, metanil yellow is widely used in the coating of turmeric It is extensively used in paper, leather, and many textile industries as a dye and colorant for the wool [1, 2]. Cumulative data showed that bees’ honey possesses a considerable anti-inflammatory, antioxidative, and antitumor activity. It is considered a potent radical scavenger especially for hydroxyl radicals. The present study aims to evaluate the hepatotoxic effects of metanil yellow as well as the hepatoprotective effects of bees’ honey on rat liver. This study aims to investigate a possible pathway for the protective effect of bees’ honey
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