Bee venom injection significantly reduces atopic dermatitis in the mouse

Abstract

Event Abstract Back to Event Bee venom injection significantly reduces atopic dermatitis in the mouse Bong-Jun Sur1*, Jong-Bong Park1, Hye-Jung Lee1, Insop Shim2 and Dae-Hyun Hahm1 1 Kyung Hee University, Acupuncture and Meridian Science Research Center, South Korea 2 The Catholic University of Korea, Department of Integrative Medicine, College of Medicine, South Korea Atopic dermatitis (AD) is one of the most common skin diseases and its prevalence is increasing in industrialized countries. This disease requires safe and effective pharmacological therapies with little side effects. In mice, trimellitic anhydride (TMA) is routinely used to trigger T-cell-dependent contact hypersensitivity (CHS) reactions. In order to investigate whether Bee venom (BV) acupuncture influenced atopic dermatitis-induced skin impairments, we performed the chronic models of TMA-induced ear inflammation using BALB/c mice. In the chronic model for AD, animals received 5 % TAM on day 5 on the dorsum of both ears and challenges with 2 % TMA on days 6-14 on the ears. Treatment therapy was performed with BV (30 mg/kg) acupuncture to P40 acupoint once daily for 6 days 30 min before TMA injection. In this model closely reflects characteristics of AD, such as evaluating ear thickness, typical morphological changes of the inflamed skin, the expression of target genes, IL-4 and IL- ã and strong increase of serum IgE and IL-4 levels. Similarly pretreatment with prednisolone (30 mg/kgm p.o.), BV acupuncture significantly reduced the expression of skin inflammation and serum IgE and IL-4 levels after chronic TMA-induced AD model, compared to tail acupuncture control group. These results provide evidence that BV acupuncture may be effective for inhibiting the skin inflammation of AD by possible modulation of the immune system. This work was supported by the Korea Science and Engineering Foundation (KOSEF) grant funded by the Korea government (MEST) (R11-2005-014). Conference: 41st European Brain and Behaviour Society Meeting, Rhodes Island, Greece, 13 Sep - 18 Sep, 2009. Presentation Type: Poster Presentation Topic: Poster presentations Citation: Sur B, Park J, Lee H, Shim I and Hahm D (2009). Bee venom injection significantly reduces atopic dermatitis in the mouse. Conference Abstract: 41st European Brain and Behaviour Society Meeting. doi: 10.3389/conf.neuro.08.2009.09.314 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 15 Jun 2009; Published Online: 15 Jun 2009. * Correspondence: Bong-Jun Sur, Kyung Hee University, Acupuncture and Meridian Science Research Center, Seoul, South Korea, surzeus@naver.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Bong-Jun Sur Jong-Bong Park Hye-Jung Lee Insop Shim Dae-Hyun Hahm Google Bong-Jun Sur Jong-Bong Park Hye-Jung Lee Insop Shim Dae-Hyun Hahm Google Scholar Bong-Jun Sur Jong-Bong Park Hye-Jung Lee Insop Shim Dae-Hyun Hahm PubMed Bong-Jun Sur Jong-Bong Park Hye-Jung Lee Insop Shim Dae-Hyun Hahm Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.