Abstract
: Natural products have been known as one of the most important therapeutic agents for diabetes and hyperlipidemia. Bee venom is a multipurpose agent that contains different bioactive compounds including melittin and phospholipase A2. Aim: The aim of this study was to investigate the effects of bee venom on biochemical and histopathological abnormalities in pancreas, liver and kidney of diabetic hyperlipidemic rats compared to synthetic drugs (Metformin and Atorvastatin).Material and methods: Bee venom's median lethal dose (LD50) was determined, and then 50 adult male albino rats were divided into five groups: group 1 was fed standard diet and served as a negative control group, while the other four groups were received streptozotocin and nicotinamide injections to induce type 2 diabetes and after diabetes confirmation, rats were fed a high-fat diet for 28 days and then they were divided as follows: group 2 : served as a positive control group, and the remaining three groups represented the treated groups, group 3: bee venom treated group (0.5mg/kg), group
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