Abstract
Honey, propolis, bee pollen, bee bread, royal jelly, beeswax and bee venom are natural products which have been used in medicine since ancient times. Nowadays, studies indicate that natural bee products can be used for skin treatment and care. Biological properties of these products are related to flavonoids they contain like: chrysin, apigenin, kaempferol, quercetin, galangin, pinocembrin or naringenin. Several pharmacological activities of phenolic acids and flavonoids, and also 10-hydroxy-trans-2-decenoic acid, which is present in royal jelly, have been reported. Royal jelly has multitude of pharmacological activities: antibiotic, antiinflammatory, antiallergenic, tonic and antiaging. Honey, propolis and pollen are used to heal burn wounds, and they possess numerous functional properties such as: antibacterial, anti-inflammatory, antioxidant, disinfectant, antifungal and antiviral. Beeswax is used for production of cosmetics and ointments in pharmacy. Due to a large number of biological activities, bee products could be considered as important ingredients in medicines and cosmetics applied to skin.
Highlights
Nowadays, alternative medicine, which employs natural biologically active substances obtained from bee products, is getting more and more attention
Anti-inflammatory and immunomodulatory activities of royal jelly were used to treat atopic dermatitis, hypertrophy, hyperkeratosis and epidermis and dermis inflammation, possibly through a blend of tumor necrosis factor (TNF)-specific low adjustment of IFN-gamma specific production and high adjustment of nitric-oxide synthase (NOS) expression [70]. 10-hydroxy-trans-2-decenoic acid, which is present in royal jelly, stimulates fibroblast production of collagen by inducting the production of transforming growth factor
CD14 expression in tissue which has been injected. These (TLR2) and CD14 expression in tissue which has been injected C. acnes. These results indicate that indicate that bee venom can be used as anti-acne agent
Summary
Alternative medicine, which employs natural biologically active substances obtained from bee products, is getting more and more attention. The effect of bee products on the skin has been proved by numerous studies, and the use of honey, propolis, bee pollen and bee venom in wound healing highlights their curative value [1,2,3,4]. Propolis, bee pollen, bee bread, beeswax and bee venom are the bee products which are used for medicinal purposes and cosmetic production. Bee venom called apitoxin produced by honeybee. It consists a complex mixture of different peptides and mast cell degranulating peptide, which therapeutic and cosmetic properties are used in many areas [8]
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