Abstract
A woman with extremely drug-resistant tuberculosis treated with a drug regimen including linezolid and bedaquiline during her last 3 weeks of pregnancy gave birth to a child without abnormalities. No fetal toxicities were noted by 2 years after delivery. This drug combination might be safe during the late third trimester of pregnancy.
Highlights
A woman with extremely drug-resistant tuberculosis treated with a drug regimen including linezolid and bedaquiline during her last 3 weeks of pregnancy gave birth to a child without abnormalities
In 2014, a total of 480,000 cases of multidrug-resistant tuberculosis (MDR TB) were present worldwide; 9% of these cases were resistant to fluoroquinolones and aminoglycosides (1 of the 3 available injectable secondline drugs), thereby defining them as extensively drug-resistant TB (XDR TB) [1]
Bedaquiline efficacy has been demonstrated in MDR TB and is recommended by the World Health Organization for the treatment of MDR TB [4]
Summary
A woman with extremely drug-resistant tuberculosis treated with a drug regimen including linezolid and bedaquiline during her last 3 weeks of pregnancy gave birth to a child without abnormalities. Considering the severity of XDR TB, pregnant women with this form of TB need to be effectively treated before delivery. Linezolid is an effective drug for treating XDR TB, but side effects such as neurotoxicity and hematologic toxicity frequently occur [6].
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