Abstract
Beauvericin is a cyclic hexadepsipeptide mycotoxin, which has insecticidal, antimicrobial, antiviral and cytotoxic activities. It is a potential agent for pesticides and medicines. This paper reviews the bioactivity, fermentation and biosynthesis of the fungal product beauvericin.
Highlights
Beauvericin is a famous mycotoxin produced by many fungi, such as Beaveria bassiana and Fusarium spp. [1,2]
Beauvericin is a cyclic hexadepsipeptide (Figure 1) that belongs to the enniatin antibiotic family
It is structurally similar to the enniatins, which are produced by a number of Fusarium species, but beauvericin differs in the nature of the N-methylamino acid
Summary
Beauvericin is a famous mycotoxin produced by many fungi, such as Beaveria bassiana and Fusarium spp. [1,2]. Beauvericin is a famous mycotoxin produced by many fungi, such as Beaveria bassiana and Fusarium spp. Beauvericin is a cyclic hexadepsipeptide (Figure 1) that belongs to the enniatin antibiotic family. It contains three D-hydroxyisovaleryl and three N-methylphenylalanyl residues in an alternating sequence [1,3]. It is structurally similar to the enniatins, which are produced by a number of Fusarium species, but beauvericin differs in the nature of the N-methylamino acid. Owing to this difference between beauvericin and the enniatins, their bioactivities are obviously different [4]. There is no review about the biological activity and biosynthesis of beauvericin; this review is the first to focus on the bioactivity, fermentation and biosynthesis of beauvericin
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