Abstract
A new study for a boron neutron capture therapy irradiation facility, based on a 2.5 MeV proton accelerator on a thick Li target as neutron converter, is presented here. The beam shaping assembly (BSA) modeling has been performed with the use of the MCNP5 Monte Carlo code. The fast (i.e., > 10 keV) neutron component yielded by the 7Li(p,n)7Be reaction is slowed down through TiF3 neutron spectrum shifter, while to obtain a high-quality epithermal neutron beam at the beam port exit additional layers for thermal neutrons removal and shielding of gamma rays were used. Moreover, 60Ni and Ti6Al14V were selected to filter out and further remove the residual fast neutron component, while cadmium was chosen as thermal neutrons absorber, and bismuth was selected for gamma rays shielding. The therapeutic effectiveness of the proposed BSA was evaluated by performing a set of dose-equivalent distribution calculations in a standard Snyder head phantom. The simulation results show that the proposed BSA modeling meets all the recommended by IAEA criteria and provides one possible technical choice for an accelerator-based BNCT irradiation facility in a hospital environment.
Highlights
Neutrons can diffuse inside matter before interacting, due to the null electric charge
Bismuth (Bi) was selected as gamma ray shielding material, cadmium (Cd) as thermal neutron absorber and lithiated polyethylene was chosen as delimiter to manage the size of the beam aperture
A beam shaping assembly (BSA) modeling based on a proton accelerator and a Li thick target has been studied through MCNP5 calculations as a possible, accelerator-based spectrum shifter system for a possible boron neutron capture therapy (BNCT) irradiation facility
Summary
Neutrons can diffuse inside matter before interacting, due to the null electric charge. Despite the progress achieved so far, there are types of cancers, e.g., the glioblastoma multiforme, recurrent cancers of the head, neck and liver where the conventional treatment methods, such as surgery, chemotherapy and radiotherapy have revealed to be less effective. For these types of cancers, BNCT might represent an interesting alternative therapeutic approach. BNCT is a binary treatment modality: First a 10B carrier drug is delivered into the patient body toward the
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