Abstract
Be resistant to apoptosis: a host factor from gingival fibroblasts.
Highlights
Bacteria are the main cause of infectious diseases
Millions of bacteria colonized around gingival tissue can cause periodontal diseases.[1]
Periodontitis is classified as a disease of dysbiosis, where imbalanced host–microbe interaction is considered as a main reason for disease initiation and progression.[4]
Summary
Bacteria are the main cause of infectious diseases. Millions of bacteria colonized around gingival tissue can cause periodontal diseases.[1]. Millions of bacteria colonized around gingival tissue can cause periodontal diseases.[1] When dental plaque (bacteria) accumulates, the proportion of gram-negative and anaerobic bacteria increases for the release of endotoxin and bacterial debris (including lipopolysaccharide, LPS) into the gingivae. Gingivitis represents a host–microbe homeostasis at the periodontal tissue, where the natural accumulation of microorganisms results in a limited and local host response without permanent damage to the host (mild inflammation).[4] On the contrary, chronic periodontitis, an irreversible periodontal disease (severe inflammation), represents an uncontrolled host response.
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