Abstract
Background: Glioblastomas with an oligodendroglioma component (GBMO) represents a pathology entity with indefinite diagnostic criterion and controversial prognosis, which prevents it from clinical application. The aim of this study is to disclose the clinical and genetic features of GBMO. Methods: A total of 169 glioblastoma multiforme (GBM) and 86 GBMO were reviewed. To reduce bias in patient selection, propensity score analysis was performed, and 68 pairs of GBMO-GBM were thereby generated. The survival time of the two groups was compared using the Kaplan–Meier method. Independent predictors of survival were identified using the Cox proportional-hazards model. Results: Compared to GBM, GBMO was correlated with younger age, higher frequencies of isocitrate dehydrogenase (IDH) mutation, and 1p19q co-deletion (P
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