Abstract
Objective: To explore the distribution characteristics of BDNF gene frequency in Li and Han nationalities in Hainan province. Methods: In June 2018-2019 and march to the people’s hospital of Hainan province health volunteers, 152 cases (Li 80, Han, 72), the application of polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method to detect the polymorphism of BDNF gene (rs6265), and compared with other countries and regions of ethnic comparison between BDNF gene frequency distribution. Results: No statistical difference was found in rs6265 genotype distribution of BDNF gene in Li and Han ethnic groups (P = 0.3358, P = 0.0892, P = 0.1549). Comparison of BDNF allele frequency between Li and other ethnic groups showed statistically significant differences with other ethnic groups in China and Europe (P = 0.0384, P = 0.0000), but not statistically significant differences with Japan (P = 0.1164). Conclusion: BDNF gene (rs6265) has polymorphism in both Li and Han ethnic groups in Hainan Province. Compared with ethnic groups in other countries and regions, the polymorphism distribution is ethnically different.
Highlights
Brain-derived neum promoter factor gene (BDNF) polymorphism locus RS6265 was selected to analyze the distribution of alleles and genotype frequency in Li and Han ethnic populations in Hainan province, and compared with ethnic populations in other countries and regions, aiming to provide reference data for genetic research on BDNF gene-related diseases
The hardy-weinberg equilibrium test was carried out by goodness-fit test, and the results showed that the distribution of BDNF genotypes in the subjects was in line with the hardy-weinberg equilibrium
BDNF is the second neurotrophic factor discovered after nerve growth factor (NGF)
Summary
It is an important transcriptional suppressor gene, MeCP2, that ACTS as a target gene for central nervous system function [3] [4] [5]. It is an important candidate gene for the study of the pathogenesis of neuropsychiatric diseases. BDNF polymorphism locus RS6265 was selected to analyze the distribution of alleles and genotype frequency in Li and Han ethnic populations in Hainan province, and compared with ethnic populations in other countries and regions, aiming to provide reference data for genetic research on BDNF gene-related diseases
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