Abstract
A highly sensitive and selective Zn(II) complex based chemosensor (BDAZn-GO, GO=graphene oxide; BDA=8-[di(2-picolyl)amine-3-benzyl]-4,4-difluoro-1,3,5,7-tetramethyl-4-bora-3a,4a-diaza-s-indacene) for the efficient detection of BSA has been developed. When the mass ratio for GO:BDAZn is 1:5, a non-emission complex BDAZn-GO was obtained. The synthesized chemosensor (BDAZn-GO) is highly efficient in detecting BSA over other biomolecules. Furthermore, BDAZn-GO shows fluorescence ‘turn-on’ response with the enhancement of both emission intensity and the life time with the addition of BSA. The hydrophobic interaction and metal binding sites let BSA take BDAZn from BDAZn-GO forming stable hydrophilic fluorescence nano-spheres, which can image mitochondria in HepG-2 cells. The limit of the detection is in the range of 0.0714–1.25mg/mL and BDAZn-GO can be used in detection the content of protein in commercial fermented milk.
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