Abstract
AL Amyloidosis is a multisystem disorder of clonal plasma cells (PCs) that produce an abnormal light chain which misfolds and deposits in organs causing cellular stress, organ dysfunction and eventually death. Available therapies target PCs to stop the production of amyloidogenic light chains. The burden of clonal PCs in bone marrow (BM) is typically less in AL than in Multiple Myeloma (MM) which is potentially advantageous for immunotherapeutic strategies. B-Cell Maturation Antigen (BCMA) is a transmembrane protein that is involved in the regulation of B cell proliferation and survival as well as maturation/differentiation into PCs.
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