Abstract
Introduction Despite continued advances that have led to improved survival of patients with multiple myeloma (MM) over the years,1 MM remains largely incurable with overall survival in patients who have progressed after proteasome inhibitor (PI), immunomodulatory drug (IMID), and anti-CD38 monoclonal antibody (MoAb) therapy measured in months.2 Chimeric antigen receptor T cell (CAR-T) therapy has yielded early impressive results in the relapsed/refractory setting, with B cell maturation antigen (BCMA) as the most studied target. This review will summarize the evolution of this therapy, early results, and future directions that incrementally continue to move us closer toward that elusive cure.
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