Abstract
In TB, prophylactic immunization plays a key preventive strategy. A live attenuated vaccine called bacille CalmetteGuerin (BCG) was developed way back in 1906 by Albert Calmette and Camille Guerin. The BCG vaccine was derived from an attenuated strain of Mycobacterium bovis and first used on humans in 1921 in France [2]. Currently the vaccine is given to neonates and children as a part of universal immunization program throughout the world except in the United States. Each year the vaccine is given to about 100 million children [3]. Many BCG vaccines are licensed and available worldwide; but what is interesting to note that all are derived from the same original Mycobacterium bovis strain. Since its development, the BCG has remained one of the most used and most controversial vaccines because of many reasons.
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