Abstract
B-cell lymphomas involving Waldeyer's ring (WR) comprise heterogeneous histolopathological subtypes with a wide age range and distinctive clinical features. However, the comparison between pediatric and adult patients is scarce and limited in the literature. Thirty-three cases of B-cell lymphomas involving WR, were collected and evaluated by histolopathological, immunohistochemical and FISH analyses. The 33 cases were categorized into children and adolescents referred as pediatric group (n = 12), aged (3−19) years and the adult group (n = 21), aged (20−84) years. The pediatric group included Burkitt lymphoma (BL), diffuse large B-cell lymphoma (DLBCL) and MUM1-positive-lymphoma in 7, 3 and 2 cases, respectively. While the adult cases comprised of DLBCL, follicular lymphoma, and mucosa associated lymphoid tissue (MALT) lymphoma in 18, 2 and 1 case, respectively. Male gender was predominant in both groups with 3 folds frequency in the pediatric cases compared to 2 folds in the adults counterpart. Pediatric cases showed a significantly higher frequency of stage I disease (P = 0.019), germinal center B-cell (GCB) phenotype (P = 0.011), CD10-positive expression (P = 0.003), and MYC breaks (P = 0.029) compared to adults. However, MUM1 positive expression was less frequently detected in pediatric patients than adults (P = 0.082). BCL2 rearrangement was undetectable in both pediatric and adult groups. On the other hand, adult group had the significantly higher proportion of DLBCL (P < 0.001), BCL2 expression (P = 0.027) and stage II disease (P = 0.047) compared to pediatric group.In conclusion, B-cell lymphomas involving WR presented with a wide age range, and evident variation in clinical features, histopathological subtypes and immunophenotypes between pediatric and adult age groups.
Highlights
B-cell lymphomas involving Waldeyer’s ring (WR) comprise heterogeneous histolopathological subtypes with a wide age range and distinctive clinical features
B-cell lymphomas involving WR presented with a wide age range, and evident variation in clinical features, histopathological subtypes and immunophenotypes between pediatric and adult age groups
The 33 patients with B-cell lymphoma, with a wide age range of 3–84 years, were arbitrary classified as shown in Figure 1, into children and adolescent group (12 cases), aged 3–19 years, hereafter referred to as pediatric group, and the adult group (21 cases) aged 27–84 years
Summary
B-cell lymphomas involving Waldeyer’s ring (WR) comprise heterogeneous histolopathological subtypes with a wide age range and distinctive clinical features. WR represents one of the most common extra nodal sites for lymphoma development [2]. The most common subtypes of Non-Hodgkin’s lymphoma (NHL) involving WR, in children and adults, are Burkitt lymphoma (BL) and diffuse large B-cell lymphoma (DLBCL), respectively. Follicular lymphoma (FL) involving WR occurs in both children and adults. DLBCL involving WR displays peculiar clinicopathological features compared to nodal counterpart [3]. Patients with a GCB subtype of DLBCL were shown to have a significantly better clinical outcome than those with the non-GCB subtype [4]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
