Abstract
BackgroundThe use of Bayesian Structural Equation Model (BSEM) to evaluate the impact of TB on self-reported health related quality of life (HRQoL) of TB patients has been not studied.ObjectiveTo identify the factors that contribute to the HRQoL of TB patients using BSEM.MethodsThis is a latent variable modeling with Bayesian approach using secondary data. HRQoL data collected after one year from newly diagnosed 436 TB patients who were registered and successfully completed treatment at Government health facilities in Tiruvallur district, south India under the National TB Elimination Programme (NTEP) were used for this analysis. In this study, the four independent latent variables such as physical well–being (PW = PW1-7), mental well-being (MW = MW1-7), social well-being (SW = SW1-4) and habits were considered. The BSEM was constructed using Markov Chain Monte Carlo algorithm for identifying the factors that contribute to the HRQoL of TB patients who completed treatment.ResultsBayesian estimates were obtained using 46,300 observations after convergence and the standardized structural regression estimate of PW, MW, SW on HRQoL were 0.377 (p<0.001), 0.543 (p<0.001) and 0.208 (p<0.001) respectively. The latent variables PW, MW and SW were significantly associated with HRQoL of TB patients. The age was found to be significantly negatively associated with HRQoL of TB patients.ConclusionsThe current study demonstrated the application of BSEM in evaluating HRQoL. This methodology may be used to study precise estimates of HRQoL of TB patients in different time points.
Highlights
Tuberculosis (TB) disease causes significant negative impact on Health Related Quality of Life (HRQoL) of the patient [1]
health related quality of life (HRQoL) data collected after one year from newly diagnosed 436 TB patients who were registered and successfully completed treatment at Government health facilities in Tiruvallur district, south India under the National TB Elimination Programme (NTEP) were used for this analysis
The latent variables PW, MW and SW were significantly associated with HRQoL of TB patients
Summary
Tuberculosis (TB) disease causes significant negative impact on Health Related Quality of Life (HRQoL) of the patient [1]. Quality of life has become an instrumental outcome measure in clinical research, and advances have been made in assessing the impact of many diseases on HRQoL. HRQoL is a multidimensional concept which is evaluated by a number of different latent constructs such as physical function, general health, mental health and social relationships [3]. As these latent constructs often cannot be measured objectively and directly, they are treated as latent variables in HRQoL analysis. Editor: Mohammad Asghari Jafarabadi, Tabriz University of Medical Sciences, ISLAMIC REPUBLIC OF IRAN
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