Abstract
BackgroundSoil-transmitted helminth infections affect tens of millions of individuals in the People’s Republic of China (P.R. China). There is a need for high-resolution estimates of at-risk areas and number of people infected to enhance spatial targeting of control interventions. However, such information is not yet available for P.R. China.MethodsA geo-referenced database compiling surveys pertaining to soil-transmitted helminthiasis, carried out from 2000 onwards in P.R. China, was established. Bayesian geostatistical models relating the observed survey data with potential climatic, environmental and socioeconomic predictors were developed and used to predict at-risk areas at high spatial resolution. Predictors were extracted from remote sensing and other readily accessible open-source databases. Advanced Bayesian variable selection methods were employed to develop a parsimonious model.ResultsOur results indicate that the prevalence of soil-transmitted helminth infections in P.R. China considerably decreased from 2005 onwards. Yet, some 144 million people were estimated to be infected in 2010. High prevalence (>20%) of the roundworm Ascaris lumbricoides infection was predicted for large areas of Guizhou province, the southern part of Hubei and Sichuan provinces, while the northern part and the south-eastern coastal-line areas of P.R. China had low prevalence (<5%). High infection prevalence (>20%) with hookworm was found in Hainan, the eastern part of Sichuan and the southern part of Yunnan provinces. High infection prevalence (>20%) with the whipworm Trichuris trichiura was found in a few small areas of south P.R. China. Very low prevalence (<0.1%) of hookworm and whipworm infections were predicted for the northern parts of P.R. China.ConclusionsWe present the first model-based estimates for soil-transmitted helminth infections throughout P.R. China at high spatial resolution. Our prediction maps provide useful information for the spatial targeting of soil-transmitted helminthiasis control interventions and for long-term monitoring and surveillance in the frame of enhanced efforts to control and eliminate the public health burden of these parasitic worm infections.
Highlights
Soil-transmitted helminth infections affect tens of millions of individuals in the People’s Republic of China
Soil-transmitted helminths are a group of parasitic nematode worms causing human infection through contact with parasite eggs (Ascaris lumbricoides and Trichuris trichiura) or larvae that thrive in the warm and moist soil of the world’s tropical and subtropical countries [1]
Ethical considerations The work presented here is based on soil-transmitted helminth survey data derived from the second national survey and additional studies identified through an extensive review of the literature
Summary
Soil-transmitted helminth infections affect tens of millions of individuals in the People’s Republic of China There is a need for high-resolution estimates of at-risk areas and number of people infected to enhance spatial targeting of control interventions. Such information is not yet available for P.R. China. In P.R. China, there have been two national surveys for parasitic diseases, including soil-transmitted helminthiasis. There have been two national surveys for parasitic diseases, including soil-transmitted helminthiasis Both surveys used the Kato-Katz technique as the diagnostic approach, based on a single Kato-Katz thick smear obtained from one stool sample per individual. To overcome the challenge of parasite infections in P.R. China, in 2005, the Chinese Ministry of Health issued the “National Control Program on Important Parasitic Diseases from 2006 to 2015” with its target to reduce the prevalence of helminth infections by 70% by the year 2015 [8]. The key strategy for control was large-scale administration of anthelminthic drugs in high prevalence areas, especially targeting school-aged children and people living in rural areas [9,11]
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