Bayesian estimation of group event-related potential components (BEGEP): testing a model for synthetic and real datasets

Abstract

Objective. The spatial resolution of event-related potentials (ERPs) recorded on the head surface is quite low, since the sensors located on the scalp register mixtures of signals from several cortical sources. Bayesian models for multi-channel ERPs obtained from a group of subjects under multiple task conditions can aid in recovering signals from these sources. Approach. This study introduces a novel model that captures several important characteristics of ERP, including person-to-person variability in the magnitude and latency of source signals. Furthermore, the model takes into account that ERP noise, the main source of which is the background electroencephalogram, has the following properties: it is spatially correlated, spatially heterogeneous, and varies over time and from person to person. Bayesian inference algorithms have been developed to estimate the parameters of this model, and their performance has been evaluated through extensive experiments using synthetic data and real ERPs records in a large number of subjects (N = 351). Main results. The signal estimates obtained using these algorithms were compared with the results of the analysis of ERPs by conventional methods. This comparison showed that the use of this model is suitable for the analysis of ERPs and helps to reveal some features of source signals that are difficult to observe in their mixture signals recorded on the scalp. Significance. This study shown that the proposed method is a potentially useful tool for analyzing ERPs collected from groups of subjects in various cognitive neuroscience experiments.