Bayesian Coherence Analysis for Microcircuit Structure Learning

Abstract

Functional microcircuits model the coordinated activity of neurons and play an important role in physiological computation and behaviors. Most existing methods to learn microcircuit structures are correlation-based and often generate dense microcircuits that cannot distinguish between direct and indirect association. We treat microcircuit structure learning as a Markov blanket discovery problem and propose Bayesian Coherence Analysis (BCA) which utilizes a Bayesian network architecture called Bayesian network with inverse-tree structure to efficiently and effectively detect Markov blankets for high-dimensional neural activity data. BCA achieved balanced sensitivity and specificity on simulated data. For the real-world anterior lateral motor cortex study, BCA identified microcircuit subtypes that predicted trial types with an accuracy of 0.92. BCA is a powerful method for microcircuit structure learning.