BAY 11-7085 attenuates alcohol dependence induced spontaneous withdrawal syndrome in mice

Abstract

Upregulation of nuclear factor kappa B plays a prominent role in drug addiction. The current study explored the neuroprotective effect of BAY 11-7085, a selective nuclear factor kappa B inhibitor, on the spontaneous alcohol withdrawal syndrome in mouse model of alcohol addiction. Administration of Alcohol (2g/kg, 10%, v/v, oral), once daily for 7 days. Assessment of behavioral parameters and exploratory parameters was done on 7 day after 8 hr. of the last ethanol administration for a period of 120 minutes. Various behavioural parameters were conducted like wall climbing test, composite withdrawal severity score, anxiety like behaviour assessed in open field and elevated plus test. Treatment with BAY 11-7085 markedly and dose dependently (p<0.05) attenuated spontaneous alcohol withdrawal syndrome in mice measured in terms of withdrawal severity score, wall climbing, locomotor sensitization by open field test and anxiety. Thus, it is suggested that activation of nuclear factor kappa B pathway is involved in the development of alcohol dependence induced withdrawal syndrome. Modulation of NFK-β may be used as therapeutic agent to overcome the problems related with alcohol dependence.