Abstract
Polycystic ovary syndrome (PCOS), a hyperandrogenic disturbance commonly found in women of reproductive age (6%), can disturb normal fertility. The symptoms of PCOS include hyperandrogenism, oligomenorrhea, chronic anovulation, and hyperinsulinemia. Hyperandrogenism causes oocytes to be of poor quality (immature). Meanwhile, granulosa cell apoptosis could also affect oocyte quality. This study aimed to identify differences in the expression of the pro-apoptotic gene BCL-2–associated X (BAX) and anti-apoptotic gene B-cell lymphoma-2 (BCL-2) between patients with PCOS and healthy controls. In this cross-sectional study, 40 respondents (20 women with a confirmed diagnosis of PCOS and 20 controls) were recruited at the Yasmin IVF Clinic of Cipto Mangunkusumo Hospital (Jakarta, Indonesia). These respondents provided informed consent. BAX and BCL-2 levels were assayed using real-time PCR. There were no significant differences in terms of BAX (p = 0.38) or BCL-2 levels (p = 0.223) between the PCOS and control groups. The BAX/BCL-2 ratio was also not significantly different between the groups (p = 0.31). In conclusion, BAX/BCL-2 gene expression did not significantly differ between the patients with PCOS and control subjects. Further studies using larger sample sizes are warranted to confirm these findings.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.