Bax and TGFβRII frameshift mutations in lung cancer

Abstract

To explore frameshift mutations in the Bax and TGFβRII genes and the relationship between frameshift mutations and microsatellite alterations in lung cancer. Frameshift mutations and microsatellite alterations were detected in 50 primary lung cancer tissues by PCR,8% denature polyacrylamide gel electrophoresis and silver staining. Bax gene (G)₈ frameshift mutations were detected in 12 cases (24%，12/50),and all were base deletion mutations.Bax frameshift mutations correlated with microsatellite alterations (P<0.05).TGFβRII (A)₁₀ frameshift mutations were not found. Bax gene frameshift mutations are found in lung cancer,and closely correlate with microsatellite alterations.Bax gene and microsatellite might play a certain role in carcinogenesis of lung cancer.