Abstract
BATF2 in human colorectal cancer.
Highlights
Colorectal cancer (CRC) is one of the leading causes of cancer death worldwide
Our data showed that BATF2 overexpression downregulates MET expression by inhibiting transcription and thereby dephosphorylates Akt in CRC cells
In addition to hairy cell leukaemia and chronic myelogenous leukemia (CML), therapeutic efficacy of IFN-α2 in causing at least partial disease regression has been identified in other diverse human malignancies including melanoma, renal cell and bladder cancer, lymphoma, myeloma, and Kaposi’s sarcoma [6]
Summary
Colorectal cancer (CRC) is one of the leading causes of cancer death worldwide. Better understanding of the molecular mechanisms of CRC pathogenesis is crucial to identify new therapeutic targets and facilitate treatment decisions. Editorial studies have shown that activation of HGF/MET signaling promotes the progression of many tumors via PI3K/Akt and/or MAPK/ERK. Our data showed that BATF2 overexpression downregulates MET expression by inhibiting transcription and thereby dephosphorylates Akt in CRC cells.
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