Batch and Flow Asymmetric Catalysis for the Synthesis of Chiral Active Pharmaceutical Compounds

Abstract

first_page settings Order Article Reprints Font Type: Arial Georgia Verdana Font Size: Aa Aa Aa Line Spacing:    Column Width:    Background: Open AccessAbstract Batch and Flow Asymmetric Catalysis for the Synthesis of Chiral Active Pharmaceutical Compounds † by Maurizio Benaglia Dipartimento di Chimica, Università degli Studi di Milano, 20122 Milano, Italy † Presented at Symmetry 2017—The First International Conference on Symmetry, Barcelona, Spain, 16–18 October 2017. Proceedings 2018, 2(1), 72; https://doi.org/10.3390/proceedings2010072 Published: 3 January 2018 (This article belongs to the Proceedings of The First International Conference on Symmetry) Download Download PDF Download PDF with Cover Download XML Versions Notes Continuous-flow systems have emerged as a powerful technology for performing chemical transformations and have recently attracted attention also for the preparation of chiral APIs (active pharmaceutical ingredients).Recently developed technology-assisted stereoselective reactions will be discussed, including reactions of nitroacrylates under MW irradiation and organocatalyzed reactions in alternative reaction media (Deep Eutectic Solvents). Some stereoselective transformations have been performed in chiral organocatalytic reactors (packed-bed and monolithic) under continuous flow conditions. Recent developments will be presented, also highlighting the possibility to perform organocatalytic reactions in (micro)-mesoreactors and to synthesize in flow-mode chiral intermediates of pharmaceutical interest. Preliminary results of stereoselective catalytic reactions in 3D-printed reactors will also be briefly highlighted. © 2018 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Share and Cite MDPI and ACS Style Benaglia, M. Batch and Flow Asymmetric Catalysis for the Synthesis of Chiral Active Pharmaceutical Compounds. Proceedings 2018, 2, 72. https://doi.org/10.3390/proceedings2010072 AMA Style Benaglia M. Batch and Flow Asymmetric Catalysis for the Synthesis of Chiral Active Pharmaceutical Compounds. Proceedings. 2018; 2(1):72. https://doi.org/10.3390/proceedings2010072 Chicago/Turabian Style Benaglia, Maurizio. 2018. "Batch and Flow Asymmetric Catalysis for the Synthesis of Chiral Active Pharmaceutical Compounds" Proceedings 2, no. 1: 72. https://doi.org/10.3390/proceedings2010072 Find Other Styles Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here. Article Metrics No No Article Access Statistics Multiple requests from the same IP address are counted as one view.