Abstract
© 2011 The Authors. doi: 10.2340/00015555-1052 Journal Compilation © 2011 Acta Dermato-Venereologica. ISSN 0001-5555 Basophils are blood leukocytes that constitute less than 0.5% of total leukocytes. Basophils have been shown to infiltrate in cutaneous hypersensitivity responses in guinea pigs (cutaneous basophil hypersensitivity) (1, 2). Basophil infiltration is also observed in allergen-induced late-phase cutaneous responses in human atopic subjects (3) and has been implicated in allergic human diseases (4). Recent findings in mice have demonstrated clearly that basophils are essential initiator cells of immunoglobulin (Ig)E-mediated chronic allergic inflammation (5), and they are capable of functioning as a source of interleukin (IL)-4 and contributing to Th2-type immunity (6). Eosinophilic pustular folliculitis (EPF) is an inflammatory skin disease characterized by pruritic follicular papulopustules of unknown aetiology. Histologically, a number of eosinophils infiltrate around and into hair follicles in the dermis, whereby it is suggested that the Th2-type immune response is involved in this pathological mechanism (7). However, basophils in skin lesions have not been studied in detail because these cells, unlike eosinophils, cannot be detected by routine histological staining techniques. To address this, we performed immunohistochemical staining to detect tissue basophils in EPF lesions. MATErIALS AND METHoDS
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