Abstract
Methods DBPCFC was performed with increasing concentrations of peanut allergen (1 mg to 5 g of peanut) in 42 children with suspected IgE-mediated peanut-allergy. Blood samples were taken for analyses of CD-sens and quantification of IgE-antibodies to peanut and Ara h 1-3, 8-9. Basophils were stimulated in vitro with peanut allergen in descending doses until the threshold sensitivity was reached. CD-sens was defined on the basis of the allergen dose giving 50% of maximal basophil response, measured as expression of CD63. A positive challenge was defined as objective allergic symptoms.
Highlights
A few fatal reactions occur every year due to IgEmediated food allergy among children and teenagers, but there are considerably more near-fatal incidents
CD-sens was defined on the basis of the allergen dose giving 50% of maximal basophil response, measured as expression of CD63
A positive challenge was defined as objective allergic symptoms
Summary
Peanut allergen components in relation to DBPCFC in children with suspected peanut allergy. Caroline Nilsson1*, Susanne Glaumann, Gunnar Lilja, Magnus Borres, SGO Johansson. From Food Allergy and Anaphylaxis Meeting 2011 Venice, Italy. From Food Allergy and Anaphylaxis Meeting 2011 Venice, Italy. 17-19 February 2011
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