Abstract
Previous studies have shown that basolateral ATP inhibits vasopressin action in the renal collecting tubule. Although there is evidence for an apical P2Y 2 receptor in this tubule segment, it is not known whether apical ATP has similar effects. In the rat inner medullary collecting duct basolateral, but not apical, ATP (0.1–100 μM) reversibly inhibited vasopressin-induced increases in water permeability with an IC 50 of 1.09 μM. Basolateral UTP, but not ADP, α,β-methylene-ATP or 2-methylthio-ATP also inhibited vasopressin action. It is concluded that basolateral but not apical P2Y 2 receptors inhibit vasopressin action in the collecting duct.
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