Abstract
AIO admixtures are parenteral nutrition formulations containing water, glucose, 15–20 amino acids, lipids, 10–12 electrolytes, 9 trace elements and 11–12 vitamins in a single container. For practical reasons some medications (e.g. insulin, cimetidine and ranitidine) may be added to the admixture in order to maintain acting concentration in serum, decreasing total volume of fluids infused, reducing the risk of contamination and the cost of equipment. All these ingredients and additives and order in which they are added and ways of delivery influence the overall TPN admixture stability. Stability means that the admixture maintains the same status throughout the defined period of time (storage and delivery). Features of stability are:
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