Abstract
As a rapidly developing biomedical imaging technology,in vivo optical molecular imaging has been widely applied in various research fields owing to its unique real-time,quantitative and noninvasive characteristics.The applications of in vivo optical imaging technology in the basic and clinical research of breast cancer were reviewed,including detection of distant metastasis,tumor apoptosis,cell cycle,hypoxia and angiogenesis,ER-mediated molecular pathway,breast cancer stem cells,early diagnosis,sentinel node biopsy,evaluation of drug efficacy and detection of human epidermal growth factor receptor-2 (HER-2) expression.They all seem to have a promising potential in in vivo optical molecular imaging. Key words: Breast neoplasms; Optics; Diagnostic imaging; Luciferase
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