Abstract
Calcium phosphate cement (CPC) sets in situ to form hydroxyapatite and is highly promising for a wide range of clinical applications. However, its low strength limits its use to only non-stress applications, and its lack of macroporosity hinders cell infiltration, bone ingrowth and implant fixation. The aim of this study was to develop strong and macroporous CPC scaffolds by incorporating chitosan and water-soluble mannitol. The incorporation of chitosan could improve the handling properties of CPC. Mannitol provided the needed early strength of CPC and then dissolved to create macropores for tissue ingrowth. This study investigated the effects of mannitol volume fraction (0-70%) on CPC composite mechanical properties and macroporosity of the scaffold after mannitol dissolution.
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