Abstract
A number of important musculotropic spasmolytic agents are esters of aminoalcohols and arylaliphatic acids, and their activity appears to depend to some degree on the number and complexity of the aryl groups or related hydroaromatic groups in the acid moiety. Cyclopropanecarboxylic acid can be modified by substitution with aryl groups to produce a greater variety of compounds than is possible by similar substitution of the more frequently encountered acyclic aliphatic acids. Several cyclopropanecarboxylic acids have been prepared by the reaction of ethyl diazoacetate with the appropriate hydrocarbon or diphenyldiazomethane with ethyl cinnamate, and converted to aminoalkyl esters in the usual way. By such reactions the following esters have been prepared: diethylaminoethyl 2,2-diphenylcyclopropanecarboxylate; diethylaminoethyl 2,3-diphenylcyclopropanecarboxylare;diethylaminoethyl 2,2,3-triphenylcyclopropanecarboxylate; and diethylaminoethyl dibenzonorcaradienecarboxylate.
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